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微流控LNP,微流控脂質(zhì)體,微流控包載,微流控mRNA主要應(yīng)用
◆食品乳化 Food emulsification
◆制劑乳化 Preparation emulsification
◆化妝品乳化 Cosmetic emulsification
◆生物制劑 Biological preparations
微流控LNP,微流控包載,微流控mRNA原理介紹
Principle Introduction
可實(shí)現(xiàn)樣品的初乳化、復(fù)乳化、粒徑控制功能。
Can realize the functions of initial emulsification, re-emulsification and particle size control.
微流控乳化系統(tǒng)通過(guò)制備泵和高壓輸送泵與微流控芯片相連接，A相和B相可按照一定的比例恒速的輸送至芯片中進(jìn)行混合，乳化。在微流控芯片中通過(guò)設(shè)計(jì)不同的流道結(jié)構(gòu)，控制不同的速度，使得樣品在微流控芯片中達(dá)到湍流、層流或霧化狀態(tài)，可以實(shí)現(xiàn)樣品的初乳化或復(fù)乳化的要求。
Microfluidic emulsification system is connected with microfluidic chip by fabricating pump and high-pressure conveying pump. Phase A and phase B can be mixed and emulsified at constant speed in a certain proportion. In microfluidic chips, different runner structures are designed and different velocities are controlled to make the samples turbulent, laminar or atomized in the microfluidic chips, which can meet the requirements of pre-emulsification or re-emulsification.
制備好的樣品通過(guò)高壓泵輸送至高壓微流控芯片中，通過(guò)撞擊力和剪切力來(lái)控制粒徑，使其達(dá)到所需范圍內(nèi)。粒徑小可達(dá)到100nm以內(nèi)，PDI至0.1以下。
The prepared samples were transported to the high pressure microfluidic chip by high-pressure pump, and the particle size was controlled by impact force and shear force to reach the required range. The smallest particle size can be less than 100nm, and PDI can be less than 0.1.
技術(shù)參數(shù)
Technical Parameter
流量范圍（ml/min） Flow range | 0.1～200 | 流量連續(xù)可調(diào) Continuously adjustable flow rate |
壓力范圍（MPa） Pressure | 0-25 | 具有高低壓保護(hù)功能 High and low voltage protection function |
溫度控制（℃） Temperature | ～100℃ | / |
流量設(shè)定誤差%（ml/min） Flow rate error | ≤±1% | / |
流量重復(fù)性誤差%（ml/min） Flow repeatability error | ≤1% | / |
壓力脈動(dòng)（MPa） Pressure fluctuation | ≤0.1 | / |
壓力準(zhǔn)確度（MPa） Pressure accuracy | ≤0.1 | / |
芯片通道尺寸 Chip channel size | 20um~1mm | 二通道，三通道，四通多或其他 Two-way, three-way, four-way or more |
微流控LNP,微流控脂質(zhì)體,微流控包載,微流控mRNA
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